许丽霞,女,2014年博士毕业于香港中文大学,博士期间至澳大利亚国立大学合作交流。现为中山大学附属第一医院肿瘤科博士生导师。主要从事消化系统肿瘤转移的机制及干预研究,阐明了多个基因通过调控肿瘤微环境促进肿瘤侵袭及转移的机制,揭示了肝癌患者不同肝内转移灶对靶向治疗、免疫治疗产生差异应答的机制。业绩,迄今为止共发表学术论文三十余篇,以(共同)第一作者或通讯作者在Gut(2篇)、Annals of Oncology、Clinical Cancer Research等肿瘤学权威杂志发表SCI论著10篇(4篇IF>10)。获国际消化疾病大会(IDDF)杰出青年学者奖,入选广东省杰出青年、广州市珠江科技新星、中山大学附属第一医院柯麟新锐人才及优秀青年人才支持计划,获广东省科技进步一等奖(6/15),获国内外授权专利4项,共5次受邀在美国消化疾病周(DDW)口头发言。代表性论著,1. Xu L, He M, Dai Z, et al. Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma. Annals of oncology. 2019. 30(6): 990-997. (IF: 18.274) 2. Xu L, Li X, Cai M, et al, Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer. Gut. 2016. 65(4):635-46. (IF: 19.819)3. Huang M, He M… Xu L, et al. The influence of immune heterogeneity on the effectiveness of immune checkpoint inhibitors in multifocal hepatocellular carcinomas. Clinical Cancer Research. 2020. 26(18):4947-4957.(共同通讯)(IF: 10.107)4. Xu L, Li X, Chu ES, et al. Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer. Gut. 2012. 61(7):977-985. (IF: 19.819) 5. Tan L, Chen S, … Xu L, et al. Sublethal heat treatment of hepatocellular carcinoma promotes intrahepatic metastasis and stemness in a VEGFR1-dependent manner. Cancer Letters. 2019. 460: 29-40.(共同通讯)(IF: 7.360)6. Huang L, Zhai E, … Xu L, et al. Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway. Journal of Experimental & Clinical Cancer Research. 2018. 37(1):6.(共同通讯)(IF: 7.068)
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